Interleukin-4 (IL-4) Inhibits Secretion of IL-lfl, Tumor Necrosis Factor a, and IL-6 by Human Monocytes
نویسنده
چکیده
Monocytes activated by lipopolysaccharide (LPS) and interferon y (IFNy) rapidly secrete a number of monokines with different functional properties. Interleukin-4 (IL-41, a T-cell derived cytokine, has been shown to reduce the production of monokines with cytostatic activity for tumor cells, chemotactic activity for monocytes, and factors that stimulate thymocyte proliferation. This latter activity is mediated by a number of monokines like IL-1, tumor necrosis factor a (TNFa), and IL-6. To elucidate which cytokines produced by monocytes are controlled by IL-4, we tested the effect of IL-4 on the secretion of IL-1 a, IL-la, TNFa, and IL-6 induced by LPS or IFNy. IL-4 was found to inhibit the secretion of IL-1s and TNFa by activated monocytes
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تاریخ انتشار 2003